Pseudouridylation of 7 SK sn RNA promotes 7 SK sn RNP formation to suppress HIV ‐1 transcription and escape from latency

Pseudouridylation of 7SK snRNA promotes 7SK snRNP formation to suppress HIV-1 transcription and escape from latency.

The 7SK snRNA sequesters P-TEFb, a general transcription elongation factor and human co-factor for HIV-1 Tat protein, into the catalytically inactive 7SK snRNP Little is known about how 7SK RNA is regulated to perform this function. Here, we show that most of 7SK is pseudouridylated at position U250 by the predominant cellular pseudouridine synthase machinery, the DKC1-box H/ACA RNP Pseudouridy...

Isospin dependent multifragmentation in 112 Sn 1 112 Sn and 124 Sn 1 124 Sn collisions

Percolation models have proven highly successful in the simulation of multifragmentation reactions in the past @1,2#. Within these models, fragmentation is described by first distributing a set of points or sites, each representing a nucleon, on a three-dimensional lattice, which represents the bonds between the sites. In the case of a simple rectangular lattice, each site is connected to six n...

Neurospora spore killers Sk-2 and Sk-3 suppress meiotic silencing by unpaired DNA.

In Neurospora crassa, pairing of homologous DNA segments is monitored during meiotic prophase I. Any genes not paired with a homolog, as well as any paired homologs of that gene, are silenced during the sexual phase by a mechanism known as meiotic silencing by unpaired DNA (MSUD). Two genes required for MSUD have been described previously: sad-1 (suppressor of ascus dominance), encoding an RNA-...

Groningen Optical spectroscopy of complex open - 4 d - shell ions Sn 7 + - Sn 10 +

Epitaxial growth and interfacial structure of Sn on Si(111)-(7 7)

Room temperature stabilization of up to 3.5 ML epitaxial metastable a-Sn at the Si(1 1 1)-(7 7) surface is reported. The a-Sn layers remain stabilized at the interface even after the deposition of thick Sn layers that undergo the a-Sn ! b-Sn transformation. Additionally, a small decrease in the s-electron density at the Sn nucleus is found for submonolayer of Sn at the Sn/Si(1 1 1)-(7 7) interf...